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Prospective Subunit Nanovaccine against < em > Mycobacterium tuberculosis < /em > Infection ─Cubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6' Dimycolate
ACS Appl Mater Interfaces. 2023 Jun 1. doi: 10.1021/acsami.3c04063. Online ahead of print.ABSTRACTAn improved vaccine is urgently needed to replace the now more than 100-year-old Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis (TB) disease, which represents a significant burden on global public health. Mycolic acid, or cord factor trehalose 6,6' dimycolate (TDM), a lipid component abundant in the cell wall of the pathogen Mycobacterium tuberculosis (MTB), has been shown to have strong immunostimulatory activity but remains underexplored due to its high toxicity and poor solubility. Herein, we employed a novel ...
Source: Cancer Control - June 1, 2023 Category: Cancer & Oncology Authors: Sampa Sarkar Abhishek Mishra Selvakannan Periasamy Brendan Dyett Prashant Dogra Andrew S Ball Leslie Y Yeo Jacinta F White Zhihui Wang Vittorio Cristini Chinnaswamy Jagannath Arshad Khan Sarvesh K Soni Calum J Drummond Charlotte E Conn Source Type: research

The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside
We describe their potential uses for efficacy and toxicity assessments, to optimise the drug development process and reduce the high failure rates in clinical trials.PMID:37067473 | DOI:10.1177/02611929231170392
Source: Alternatives to Laboratory Animals : ATLA - April 17, 2023 Category: Research Authors: Artur C G da Silva Marize C Valadares Source Type: research

Highlights into historical and current immune interventions for cancer
Int Immunopharmacol. 2023 Feb 27;117:109882. doi: 10.1016/j.intimp.2023.109882. Online ahead of print.ABSTRACTImmunotherapy is an additional pillar when combined with traditional standards of care such as chemotherapy, radiotherapy, and surgery for cancer patients. It has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapies, including adoptive cellular therapy (ACT) and checkpoint inhibitors (CPIs), can induce durable clinical responses. However, their efficacies vary, and only subsets of cancer patients benefit from their use. In this review, we address three goal...
Source: International Immunopharmacology - February 27, 2023 Category: Allergy & Immunology Authors: Kathryn Cole Zaid Al-Kadhimi James E Talmadge Source Type: research

Indirect effects of cytomegalovirus infection: Implications for vaccine development
Rev Med Virol. 2022 Nov 15:e2405. doi: 10.1002/rmv.2405. Online ahead of print.ABSTRACTDevelopment of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact-contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non-genetic sensorineural hearing loss. The impact of CMV on the general population has been less well studied; however, a wide range of evidence indicates that CMV may increase the risk of atherosclerosis, cancer, immunosenescence, and progression of tuberculosis (TB) and human immunodeficiency virus. Due to the high seroprevale...
Source: Atherosclerosis - November 15, 2022 Category: Cardiology Authors: Philip Moseley Paul Klenerman Seilesh Kadambari Source Type: research

Implications of the non-specific effect induced by Bacillus Calmette-Guerin (BCG) vaccine on vaccine recommendations
CONCLUSIONS: Despite evidence obtained from in vitro studies, and some epidemiological and clinical evidence, more robust evidence of in vivo efficacy is still needed to justify the use of BCG in clinical practice, in addition to what is recommended by the National Immunization Program for TB prevention and bladder cancer treatment.PMID:36309066 | DOI:10.1016/j.jped.2022.09.002
Source: Jornal de Pediatria - October 29, 2022 Category: Pediatrics Authors: Ekaterini Goudouris Carolina Sanchez Aranda Dirceu Sol é Source Type: research

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